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gene based gene environment interaction in twin studies

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yaning's picture
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Joined: 04/12/2019 - 09:29
gene based gene environment interaction in twin studies

Hello, everyone
I’m going to explore gene environment interaction based gene in twin studies. I’ve searched for literatures, and found general/generalized linear mixed model framework of ACE model may be good choices(https://www.ncbi.nlm.nih.gov/pubmed/28953253).
Unfortunately, I'm terrible at math and basic theory. And I cannot find the relevant code.
So I want to ask if anyone has done any research that can give some help.
Thank you!

AdminNeale's picture
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Joined: 03/01/2013 - 14:09
Code might not exist

Hi

There have been some multilevel implementations of twin models that may help. Otherwise, it looks like you need a GxE Purcell-type script (where variants affect the influence of latent A, C and E components). Umx has good facilities for this kind of model https://github.com/tbates/umx