gene based gene environment interaction in twin studies
Posted on
yaning
Joined: 04/12/2019
Forums
Hello, everyone
I’m going to explore gene environment interaction based gene in twin studies. I’ve searched for literatures, and found general/generalized linear mixed model framework of ACE model may be good choices(https://www.ncbi.nlm.nih.gov/pubmed/28953253).
Unfortunately, I'm terrible at math and basic theory. And I cannot find the relevant code.
So I want to ask if anyone has done any research that can give some help.
Thank you!
I’m going to explore gene environment interaction based gene in twin studies. I’ve searched for literatures, and found general/generalized linear mixed model framework of ACE model may be good choices(https://www.ncbi.nlm.nih.gov/pubmed/28953253).
Unfortunately, I'm terrible at math and basic theory. And I cannot find the relevant code.
So I want to ask if anyone has done any research that can give some help.
Thank you!
Code might not exist
There have been some multilevel implementations of twin models that may help. Otherwise, it looks like you need a GxE Purcell-type script (where variants affect the influence of latent A, C and E components). Umx has good facilities for this kind of model https://github.com/tbates/umx
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