G x E
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Dorothy Bishop
Joined: 02/04/2010
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I'm trying to understand the analysis used in a paper that has recently created a splash in Science:
Taylor, J., Roehrig, A. D., Hensler, B. S., Connor, C. M., & Schatschneider, C. (2010). Teacher quality moderates the genetic effects on early reading. Science, 328, 512-514.
They have used a moderator variable analysis described by:Purcell, S. (2002). Variance components models for gene-environment interaction in twin analysis. Twin Research, 6, 377-382.
This is in old Mx.
Am trying to track it down, but wondered if there is anything comparable in OpenMx?
Taylor, J., Roehrig, A. D., Hensler, B. S., Connor, C. M., & Schatschneider, C. (2010). Teacher quality moderates the genetic effects on early reading. Science, 328, 512-514.
They have used a moderator variable analysis described by:Purcell, S. (2002). Variance components models for gene-environment interaction in twin analysis. Twin Research, 6, 377-382.
This is in old Mx.
Am trying to track it down, but wondered if there is anything comparable in OpenMx?
Hi Dorothy Yes, I put a
Yes, I put a script for this together some months ago when we were first testing definition variables. It is attached. You can probably find similar on the Boulder workshop website http://ibgwww.colorado.edu/workshop2010.
It can be a bit dodgy using moderators that may be caused by, rather than cause of, the variable of interest. If the moderator is age, sex, or measured genotype, I'm ok with it. Otherwise I worry.
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In reply to Hi Dorothy Yes, I put a by neale
I agree with Mike's
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In reply to I agree with Mike's by Steve
Interesting. The moderator
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In reply to Interesting. The moderator by Dorothy Bishop
It is perhaps time to try
LOL re: the tweet you received. The paper doesn't show this, it says "good genes will out" - once the teacher quality is high, what is left is individual differences in cognitive ability, which are largely genetic in origin. When the teacher quality is low, genetic factors don't get so much of a say in the matter. Possibly, variation in the domestic environment has more impact, although there's not much sign of C or E increasing at the low end of the distribution of teacher quality.
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