# Result for Univariate and Multivariate Genetic Models

I have a general question about univariate and multivariate genetic models. Do the ACE estimations roughly align with each other when using univariate and multivariate models (i.e., Cholesky Decomposition, Independent Pathway Model, Common Pathway Model) for the same variables? For example, if the univariate model for variable 1 shows no additive genetic factor but significant C and E, should the ACE estimation for variable 1 from the multivariate models show no A when compared with other variables? Sometimes, the best fitting model contains a latent genetic variable in an independent/common pathway model even for variable 1 with no A tested in the univariate model. Is it acceptable? Or is there something wrong with the analysis?

I get positive AICs for my univariate analysis, but negative AICs for my multivariate analysis on the same variables. Are the negative AICs acceptable?

Thanks,

Judy

## It happens. Trust multivariate

If the level of measurement is the same, and if there are thresholds they are also equivalently spaced in the two variables, then this source of difference in precision will not be the likely source. However, sample size for different traits may differ with FIML, which allows for missingness on a case-by-case basis.

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