OpenSEM Forums
noamm
Joined: 10/10/2018
Help with thinking about a non-trivial GxE twin model
Hello,
On a phenotypic level, I'm testing a model where Trait1 is moderating the effect of environment on Trait2.
However, when wanting to test my model within a genetic level, I'm having trouble to figure out what model I can use that will be most similar to the claim I have within the phenotypic level.
I can test whether my environmental factor moderates the genetic effects of Trait2 (with a GxE twin model). But this misses the part where Trait1 (which is highly heritable), moderates the association (or maybe the moderation?).
jeff.harring
Joined: 05/11/2012
Training Data
Does Mx allow for training data for mixture models--that is can one specify that the first 10 cases in a data set belong to class number 1 or that the last 15 cases belong to class number 3?
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Chen SJ
Joined: 04/02/2020
doubt with univariate moderation result
Hi everyone!
I am trying to run a univariate moderation model with binary moderator(smoke or not) and binary outcome(T2DM or not). However, I have doubts about the result. I have run a full moderation model ( I chose the ACE model, because when calculating the heritability of T2DM and smoke separately, the ACE model was the best fitted model for both of them) and several nested models. Nested models are compared with the full model by Chi square test. The best model is chosed by the Chi square test(p>0.05) and the smallest AIC.
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Leo
Joined: 01/09/2020
Longitudinal modeling with extended twin design
Hey,
I have a couple of questions regarding my research and I would really appreciate getting some feedback if my undertaking is reasonable.
I am investigating stability of a political phenotype in a two-wave panel design. I'm including not only twins in my analysis, but also one non-twin full sibling. The scripts are standing and working (verified with replication).
Leo
Joined: 01/09/2020
GxE with ordinal manifest in RAM
Hi,
I'm trying to build a Purcell style GxE model in RAM. I have not found any script for this so I created it from scratch. Right now I have a two ordinal manifests (twin 1, twin 2, same phenotype, 4 cats, 3threshs). The moderator will be continuous in the end. However, right now for experimental reasons I have created a binary moderator (sex) for me to easily check if my model does produce accurate results.
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Leo
Joined: 01/09/2020
Benny
Joined: 05/15/2020
khusmann
Joined: 08/11/2019
Error in runHelper... xn out of range
Hello,
I'm running a relatively complex model with binary outcomes (but well under the max 20 ordinal vars). I'm fixing mean=0, var=1 and letting thresholds vary. Things periodically fail with:
error in runHelper(model, frontendStart, intervals, silent, suppressWarnings, : xn out of range
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valentinav
Joined: 06/15/2020
ACE output: what is the p
Hi All,
I run the ACE model and got a summary table which reports the p among others.
The p is also not clear to me. Apparently it is higher for the winning model, but what exactly is this p?
Thanks,
Valentina
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Leo
Joined: 01/09/2020
ACE RAM model with ordinal manifest
Hi.
I've been trying everything to get an ordinal manifest working in RAM models but I can't get it done. Also, didn't find anything online about this, as most examples have matrix specification. Would be very appreciated to get some help. Besides from the solution below, I have also tried every possible way with mxthreshold and umxthresholdmatrix.
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