Hello,
On a phenotypic level, I'm testing a model where Trait1 is moderating the effect of environment on Trait2.
However, when wanting to test my model within a genetic level, I'm having trouble to figure out what model I can use that will be most similar to the claim I have within the phenotypic level.
I can test whether my environmental factor moderates the genetic effects of Trait2 (with a GxE twin model). But this misses the part where Trait1 (which is highly heritable), moderates the association (or maybe the moderation?).
I'm familiar mainly with basic ACE models (multivariate, sex-limitation, basic GxE), so I have no idea if there's an option to build a model more suitable for my hypothesis, or even what such a model looks like.
I would appreciate any thoughts or ideas on the matter,
Thanks!
Noam