Behavioral Genetics Models

Posted on
No user picture. MAchterberg Joined: 02/20/2017

ACE model error: In model 'ACE' Optimizer returned a non-zero status code 6.

Hello,

I am quite new to behavioral genetic modelling and I have a question about an error that I am receiving since the OpenMX update.
I have used the same scripts as before the update, but my results are very different.
in addition, I now get the error:
In model 'ACE' Optimizer returned a non-zero status code 6. The model does not satisfy the first-order optimality conditions to the required accuracy, and no improved point for the merit function could be found during the final linesearch (Mx status RED)

Posted on
No user picture. JuliaJoplin Joined: 10/12/2014

Bivariate Cholesky - Continuous & Ordinal, with Covariates

I still consider myself a BG novice, and just when I think I've gone as deep as I'll ever go, something else comes along! Awhile ago, the folks on this board graciously helped me do a bivariate Cholesky decomposition of two variables (caster and ogo). The two variables were assessed at different time points, so one variable needed to be adjusted for age1 and sex, the other variable for age2 and sex. We came up with a successful script (attached).

Posted on
Picture of user. bwiernik Joined: 01/30/2014

Latent variable Cholesky ACE model--Singular A and C matrices

I'm running a model with a Cholesky decomposition on a set of latent variables for the Big Five trait. When I run the model, the estimated phenotypic covariance (A+C+E) matrix among the latent variables Big Five variables and the E matrix are fine, but the A and C matrices are both singular. The diagonal elements of C are all near zero, so I'm not surprised by that one. Several of the estimated genetic correlations for A are extremely high (.80-.90).

Posted on
No user picture. Liz Joined: 04/20/2016

Modify the Script of Common pathway model

Dear all,

Now I'm testing a model with one observed factor and one latent factor which containing two observed factor. I'm modify a Script with two latent factors as follow (path setting part):

Posted on
No user picture. torkildl Joined: 01/31/2017

OpenMx Behavior genetics example scripts

I am looking for sets of example scripts. I have een posts for Mx examples in this forum, but not OpenMx examples.

More specifically, I am looking for scripts that estimate models With nuclear twin family designs, but also other designs are interesting.

Are there such Collections available on the internet?

Posted on
No user picture. mistral Joined: 01/20/2017

Adding siblings to saturated categorical model

Hello everyone,
I have a saturated model for categorical data with 4 categories (3 thresholds) the model is running ok for twin 1 and twin 2, but when I try to add siblings into the model I get the following error:

Error: In model 'baseModel' I was expecting 3 thresholds in column 'vars1' of matrix/algebra 'MZf.expThreshfMZ' but I hit NA values after only 0 thresholds. You need to increase the number of thresholds for 'vars1' and give them values other than NA

Posted on
No user picture. Noandria1 Joined: 01/06/2017

ACE Model

Hey guys. I am trying to do an ACE Model with my own twin data for my master thesis.
So far I had not a lot to do with statistics and also the Program R was new for me, so I spent a lot of time to get into the topic.
As basic skript I used http://openmx.psyc.virginia.edu/docs/OpenMx/2.6.7/GeneticEpi_Matrix.html

I have some questions for you and hope someone can help me with them.

Posted on
No user picture. RFrank Joined: 06/08/2012

Negative Genetic Correlation and Positive Shared Environmental Correlation?

I recently ran a bivariate cholesky script in OpenMX and am attempting to write up my results.

The results were a bit odd - I found that the genetic correlation was negative while the shared environmental correlation was positive. The phenotypic correlation is positive. If I am understanding correctly, this means that common genetic influences that serve to increase one trait will decrease the other trait, whereas the common shared environmental influences increase both traits.

Posted on
No user picture. Lola Joined: 12/28/2016

some doubts

Hi everyone,
I am really new in OpenMx. I am trying to do a bivariate analysis (dicotomic-quantitative) and I have some questions.
1-I would like to know if I should do a univariate analysis previously I mean in the bivariate analysis The best fitting model could be AE for example, for two variables but in the univariate I could have AE model for one variable and ACE model for the other variable.

Posted on
No user picture. olleee Joined: 07/28/2016

Testing for heterogeneity of total variances of MZ and DZ pairs

I'm analyzing data from a twin study and wondered if OpenMx can test for the assumption that total variances of MZ and DZ pairs are not significantly different. Any suggestion on how to perform this test would be much appreciated!