Behavioral Genetics Models
Paul Jeffries
Joined: 07/02/2021
Non-family GXE with G-->E
I used the R package gwsem to conduct a GxE analysis without the effect of G on E. However, I can not use it for the current analysis since the package does not permit a term to be a covariate and a dependent variable.
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Mirch
Joined: 10/26/2018
Negative ACE estimates in Univariate Model
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diana
Joined: 04/17/2019
Model-averaged point estimates
I am trying to calculate the heritability for some fat-related traits. I have fitted the ACE model and some submodels (CE and AE) and then learned that it was recommended to use mxModelAverage() to gain the model-averaged point estimates.
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orangeU
Joined: 05/23/2021
Longitudinal Cholesky decomposition with contrast effect
I have negative DZ correlations across multiple ages and I read that there may be a way to account for this by including a contrast effect (representing possible effects of twins within a pair on one another) in the model. Could someone please share an openMx script that does this? I have an old Mx script (attached) that accounts for a contrast effect in a classic ACE model, but I don't know how to translate it to openMx or how to integrate it in a Cholesky analysis.
Benny
Joined: 05/15/2020
Leo
Joined: 01/09/2020
Questions about biometric LGC
I'm performing biometric latent growth curve analysis with OpenMx and there a few open questions which I hope some of you might know the answer to. I have three cohorts of twins which are each surveyed three times and I am doing separate analysis of every cohort. Variation of age within cohort and wave (survey time point) is small, so I decided to feed waves into the model rather than ages (so the manifests are, phenotypes at t1, phenotype at t2 and phenotype at t3) which leads to my first question
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Qiuzhi Xie
Joined: 12/27/2018
Two or more environmental mediators in one model
sppspp10
Joined: 02/05/2021
Decomposed ACE variances...now trying to run regressions
I used this [genetic epi path specification annotated guide] (https://vipbg.vcu.edu/vipbg/OpenMx2/docs//OpenMx/latest/GeneticEpi_Path.html#ace-model-a-twin-analysis) to decompose the variances of ACE on a given phenotype (my DV).
Now, though, I need to run a regression and I can't figure out how to feed the ACE variances from above into the regressions. I assume I have to constrain the parameters somehow?
Qiuzhi Xie
Joined: 12/27/2018
OpenMx Scripts for Gene-Environment correlation (rGE)
I currently need to examine the correlation between additive gene (A) and moderators (such as SES and home language exposure). However, I don't have the OpenMx scripts to conduct rGE (gene-moderator correlation). Can anyone here provide me with an example script of rGE or tell me where I can find such scripts? I would be grateful very much!
valentinav
Joined: 06/15/2020
ACE, ADE or ACDE model
I saw papers in which they estimated ADE instead of ACE because the correlation between MZs was twice as big as the one for DZs.
So far in my analysis I used the ACE model, and I was wondering whether I should try the ACE one.
I also read of some analysis estimating ACDE model, is there any example twin I could look at?
Is the ACDE analysis impossible when twins are raised together?
Thank you very much for your help
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